Nitric oxide-releasing polymers

Details Nitric oxide-releasing polymers Nitric oxide-releasing polymers

A - Human Necessities

61

K

A61K 31/785 (2006.01) A61K 31/765 (2006.01)

Patent

CA 2555591

This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions.

Cette invention concerne des compositions renfermant des diazéniumdiolates à base de carbone fixés à des polymères hydrophobes qui libèrent du monoxyde d'azote (NO). Les polymères diazéniumdiolatés à base de carbone libèrent du monoxyde d'azote spontanément dans certaines conditions physiologiques sans formation subséquente de nitrosamine. Cette invention concerne également des procédés de préparation de ces polymères diazéniumdiolatés à base de carbone, des compositions renfermant ces polymères, des procédés d'utilisation de ces compositions et des dispositifs utilisant ces compositions renfermant ces polymères.

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