Nitric oxide-releasing polymers

A - Human Necessities – 61 – K

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A61K 31/74 (2006.01)

Patent

CA 2632683

This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present invention also relates to methods of preparing the carbon-based diazeniumdiolated polymers, compositions comprising such polymers, methods of using such compositions, and devices employing such polymer compositions

La présente invention concerne des compositions comprenant des diazéniumdiolates à base de carbone liés à des polymères hydrophobes libérant de l~oxyde nitrique (NO). Les polymères diazéniumdiolatés à base de carbone libèrent du NO spontanément dans des conditions physiologiques sans formation subséquente de nitrosamine. La présente invention concerne également des procédés de fabrication de ces polymères diazéniumdiolatés à base de carbone, des compositions comprenant de tels polymères, des procédés d~utilisation de telles compositions et des dispositifs utilisant de telles compositions polymériques.

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