C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/46 (2006.01) A61K 31/216 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2493082
The invention encompasses novel compounds of Formula I, which are nitric oxide- releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.
L'invention concerne de nouveaux composés de la formule I, qui sont des promédicaments de diaryl-2-(5H) furanones libérant de l'oxyde nitrique utiles dans le traitement de maladies induites par la cyclooxygénase-2. L'invention concerne également certaines compositions pharmaceutiques ainsi que des procédés pour le traitement de maladies induites par la cyclooxygénase-2 qui consistent à utiliser des composés de la formule I. Ces composés peuvent être utilisés dans une polythérapie avec de l'aspirine à faible dose pour traiter des maladies ou des états chroniques induites par la cyclooxygénase-2 et pour réduire simultanément le risque d'accidents cardio-vasculaires thrombotiques.
Berthelette Carl
Dufresne Claude
Lachance Nicholas
Li Lianhai
Sturino Claudio
Merck Frosst Canada & Co./merck Frosst Canada & Cie
Merck Frosst Company
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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