Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones...

Details Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones... Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones...

C - Chemistry, Metallurgy

07

C

C07C 317/46 (2006.01) A61K 31/216 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2517490

The invention encompasses novel compounds of Formula (I), which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I). The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.

L'invention concerne de nouveaux composés représentés par la formule (I), qui sont des précurseurs libérateurs d'oxyde nitrique des diaryl-2-(5H) furanones, et sont indiqués pour le traitement de pathologies dans lesquelles la cyclooxygénase-2 agit comme médiateur. (I). L'invention concerne également certaines compositions pharmaceutiques et certaines méthodes permettant de traiter les pathologies à médiateur cyclooxygénase 2, comprenant l'administration des composés représentés par la formule (I). Les composés décrits peuvent être employés dans un traitement combiné, en association avec de l'aspirine à faible dose, afin de traiter les maladies ou les troubles chroniques à médiateur cyclooxygénase 2, tout en réduisant le risque d'accidents cardio-vasculaires.

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