C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/46 (2006.01) A61K 31/04 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2554333
The invention encompasses novel compounds of Formula I, which are nitric oxide- releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenease-2 mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.
L'invention concerne des nouveaux composés de formule (I) qui sont des promédicaments libérant de l'oxyde nitrique de diaryl-2-(5h)-furanones utiles dans le traitement de maladies dont la médiation est assurée par la cyclooxygénase-2. L'invention concerne également certaines compositions pharmaceutiques et des méthodes de traitement de maladies dont la médiation est assurée par la cyclooxygénase-2 faisant intervenir lesdits composés. Ces composés peuvent être utilisés en tant que traitement combiné avec de faibles doses d'aspirine pour le traitement d'états ou de maladies chroniques dont la médiation est assurée par la cyclooxygénase-2 tout en réduisant le risque d'accidents cardiovasculaires thrombotiques.
Beaulieu Christian
Berthelette Carl
Li Lianhai
Sturino Claudio F.
Wang Zhaoyin
Merck Frosst Company
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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