Nitric oxide synthase inhibitors

Details Nitric oxide synthase inhibitors Nitric oxide synthase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/58 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2333322

The present invention relates to novel amidino compounds of formula (1), or a salt, solvate, or physiologically functional derivative thereof; wherein R1 is selected from C1-4 alkyl, C3-4 cycloalkyl, C1-4 hydroxyalkyl, and C1-4 haloalkyl; to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of inducible nitric oxide synthase.

L'invention concerne de nouveaux composés d'amidino représentés par la formule (I) ou un de leurs sels, solvates ou dérivés fonctionnels sur le plan physiologique ; dans laquelle R<1> est sélectionné dans alkyle C1-C4, cycloalkyle C3-C4, hydroxyalkyle C1-C4 et haloalkyle C1-C4; un procédé servant à les préparer, des compositions pharmaceutiques les contenant et leur mise en application thérapeutique, en particulier, en tant qu'inhibiteurs sélectifs de synthase inductible d'oxyde nitrique.

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