A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/57 (2006.01) A61K 31/195 (2006.01) A61K 38/04 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2111345
2111345 9300893 PCTABS00019 A method for treatment of an animal for systemic hypotension induced by internal nitric oxide production caused by endotoxin or cytokines. The method involves administering an .alpha.1 adrenergic agonist and an amount of an inhibitor of nitric oxide formation from arginine restoring vascular contractile sensitivity to $(a)1 adrenergic agonists. Preferable NG-substituted arginine (having at least one hydrogen on a guanidino amino group replaced by another atomic or molecular species). The inhibitor is administered to an animal having such induced systemic hypotension. Arginine derivative inhibitors are preferably of the L configuration and include pharmaceutically acceptable addition salts. Treatment of systemic hypotension in a patient which has been induced by chemotherapy with biologic response modifiers such as tumor necrosis factor or interleukin-2 may be likewise accomplished. Treatment of an animal for systemic hypotension induced by endotoxin, or other bacterial toxins, e.g., septic shock, may also be accomplished by treatment with .alpha.1 adrenergic agonists and an inhibitor such as an arginine derivative, restoring vascular contractile sensitivity to the .alpha.1 adrenergic agonists.
Gross Steven S.
Kilbourn Robert G.
Levi Roberto
Bereskin & Parr
Cornell Research Foundation Inc.
The Board Of Regents Of The University Of Texas System
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