Nitro compounds and their compositions having...

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C - Chemistry, Metallurgy

07

C

C07C 203/04 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 245/08 (2006.01) C07D 207/337 (2006.01) C07D 209/28 (2006.01) C07D 209/46 (2006.01) C07D 209/82 (2006.01) C07D 213/72 (2006.01) C07D 231/12 (2006.01) C07D 261/08 (2006.01) C07D 313/14 (2006.01) C07D 333/24 (2006.01) C07D 337/14 (2006.01) C07D 409/06 (2006.01) C07D 487/04 (2006.01) C07D 491/052 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2190087

New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A-X1-NO2 or their salts, wherein: A is R(COXu)t, wherein t is zero or 1 and u is zero or 1; and X is O, NH or NR1C wherein R1C is C1-C10 alkyl; and R is Ia) wherein R1 is acetoxy, preferably in ortho-position with respect to -CO- and R2 is hydrogen; or derivatives of acetylsalylsalicyclic acid; and X1 is -YO- wherein Y is C1-C20 alkylene, C5-C7 cycloalkylene, oxy-alkyl derivatives and oxy-methyl benzyl derivatives.

Nouveaux composés ou leurs sels et compositions les contenant qui possèdent une activité anti-inflammatoire, analgésique et antithrombotique, répondant à la formule générale A-X¿1?-NO¿2?, dans laquelle A représente R(COX¿u?)¿t?, où t vaut zéro ou 1 et u vaut zéro ou 1; et X représente O, NH ou NR¿1C?, où R¿1C? représente alcoyle C¿1?-C¿10?, et R représente un groupe (Ia) dans lequel R¿1? représente acétoxy, de préférence dans la position ortho par rapport à -CO-, et R¿2? représente hydrogène; ou des dérivés de l'acide acétylsalylsalicyclique; et X¿1? représente -YO-, où Y représente alcoylène C¿1?-C¿20?, cycloalcoylène C¿5?-C¿7?, des dérivés oxy-alcoyle et oxy-méthyle benzyle.

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