Nitro derivatives of furasemide and their use as diuretics

C - Chemistry – Metallurgy – 07 – D

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C07D 491/04 (2006.01) A61K 31/4355 (2006.01) A61P 9/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2731957

A compound having the structure wherein X is selected from the group consisting of: a bond, -NHCH2(CH2)n CH2OC(O), -CH2NHC(O)CH2NHC(O)-, -CH2OC(O), -OCH(CH3)OC(O)-, - OCH2OC(O)-, -O-, -NR1-, -CR1R3-, --(CH2)p-, -(CH2)q NR1C(O)-, -CHR5NR2C(O)-, -(CH2)q C(O)-, -(CH2)q C(O)NR1-, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.

L'invention concerne un composé ayant la structure dans laquelle X est sélectionné dans le groupe comprenant : une liaison, -NHCH2(CH2)nCH2OC(O), -CH2NHC(O)CH2NHC(O)-, -CH2OC(O), -OCH(CH3)OC(O)-, -OCH2OC(O)-, -O-, -NR1-, -CR1R3-, -(CH2)P-, -(CH2)qNR1C(O)-, -CHR5NR2C(O)-, -(CH2)qC(O)-, -(CH2)qC(O)NR1-, ou un sel pharmaceutiquement acceptable de celui-ci, et des procédés d'utilisation des composés pour traiter l'hypertension.

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