Nitroaniline-based alkylating agents and their use as prodrugs

Details Nitroaniline-based alkylating agents and their use as prodrugs Nitroaniline-based alkylating agents and their use as prodrugs

C - Chemistry, Metallurgy

07

C

C07C 237/30 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/357 (2006.01) A61K 31/5375 (2006.01) A61P 35/00 (2006.01) C07C 309/66 (2006.01) C07C 311/39 (2006.01) C07D 263/04 (2006.01) C07D 295/13 (2006.01) C07D 317/28 (2006.01)

Patent

CA 2501388

Nitroaniline-based unsymmetrical mustards of the general formula (I) ((see formula I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjuction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents.

L'invention concerne des agents asymétriques à base de nitroaniline représentés par la formule générale (I), ainsi que des méthodes de préparation et des méthodes d'utilisation de ceux-ci comme promédicaments dans la thérapie par promédicaments et enzymes dépendant des gènes (GDEPT) et dans la thérapie d'ablation cellulaire, conjointement à des nitroréductases comme cytotoxines sélectives d'hypoxie et agents anticancéreux.

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