C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/30 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/245 (2006.01) A61K 31/275 (2006.01) C07C 229/60 (2006.01) C07C 255/58 (2006.01) C07C 291/04 (2006.01) C07C 309/64 (2006.01) C07C 309/66 (2006.01) C07C 311/38 (2006.01) C07C 311/39 (2006.01) C07C 327/42 (2006.01) C07C 327/48 (2006.01) C07D 295/13 (2006.01) C07D 295/135 (2006.01) C07D 295/192 (2006.01)
Patent
CA 2124315
The invention provides nitroaniline derivatives represented by general formula (I) where the nitro group is substituted at any one of the available benzene positions 2-6; where R and A separately represent the groups NO2, CN, COOR1, CONR1R2, CSNR1R2 or SO2NR1R2 and A is substituted at any one of the available benzene positions 2-6; where B represents N(CH2CH2halogen)2 or N(CH2CH2OSO2R3)2 substituted at any one of the available benzene positions; and where R1, R2 and R3 separately represent H, or lower alkyl optionally substituted with hydroxyl, ether, carboxy or amino functions, in- cluding cyclic structures, or R1 and R2 together with the nitrogen form a heterocyclic structure, and pharmaceutical prepara- tions containing them. These compounds have activity as hypoxia-selective cytotoxins, reductively-activated prodrugs for cytotoxins, hypoxic cell radiosensitisers, and anticancer agents.
Denny William Alexander
Palmer Brian Desmond
Wilson William Robert
Auckland Uniservices Limited
Cancer Research Campaign Technology Limited
Sim & Mcburney
LandOfFree
Nitroaniline derivatives and their use as antitumor agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nitroaniline derivatives and their use as antitumor agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitroaniline derivatives and their use as antitumor agents will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1561706