Nitrobenzindoles and their use in cancer therapy

Details Nitrobenzindoles and their use in cancer therapy Nitrobenzindoles and their use in cancer therapy

C - Chemistry, Metallurgy

07

D

C07D 209/60 (2006.01) A61K 31/405 (2006.01) A61P 35/04 (2006.01) C07D 403/06 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2584702

The present invention relates generally to nitro-1,2-dihydro-3H- benzo[e]indoles and related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

L'invention concerne en général des nitro-1,2-dihydro-3H-benzo[e]indoles et leurs analogues, leur préparation et leur utilisation comme médicaments sélectifs de l'hypoxie et comme radiosensibilisateurs en thérapie cancéreuse, à la fois seuls ou en combinaison avec un rayonnement et/ou d'autres médicaments anticancéreux.

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