Nitrogen-based camptothecin derivatives

Details Nitrogen-based camptothecin derivatives Nitrogen-based camptothecin derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/22 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2439787

(20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an aminoalkanoic acid or an imidoalkanoic acid and camptothecin, wherein the compounds are of the formula: (see formula above) The compounds are useful for treating cancer.

(20S) esters d'analogues de camptothécine. Ces composés sont des (20S) esters d'un acide aminoalcanoïque ou d'un acide imidoalcanoïque et de camptothécine, éventuellement substitués aux positions 7, 9, 10, 11, et 12 du noyau camptothécine ; et sont utiles dans le traitement de cancers.

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