Nitrogen bridge tetrahydroisoquinolines

Details Nitrogen bridge tetrahydroisoquinolines Nitrogen bridge tetrahydroisoquinolines

C - Chemistry, Metallurgy

07

D

C07D 217/20 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2088436

ABSTRACT NITROGEN BRIDGE TETRAHYDROISOOUINOLINES Muscle relaxant nitrogen bridge tetrahydroisoquinolines are disclosed. The novel compounds are represented by the formula Image wherein A is -?-O- or -O-?-; M represents -(CH2)n-Z-(CH2)n or Image , R is a C1-3 alkoxy group, or adjacent Rs are a methylenedioxy group, R1 is lower alkyl; n is 1-6; m is 2 or 3; p is 1 - 3; Z is -N+(R2R3)-, -N(R4)-, -N(?-Y)- and -N[(CH2)n-A-R5]-; R2 and R3 are independently lower alkyl groups wherein a carbon atom within the chain may be replaced by a heteroatom, lower cycloalkyl, lower cycloalkyl lower alkyl, aryl, aryl lower alkyl, a 4- to 6-member heteroring or may be combined with the nitrogen to form a heteroring; R4 is a straight- or branched- chain C1-10 alkyl wherein a carbon atom within the chain may be replaced by a heteroatom, lower cycloalkyl, lower cycloalkyl lower alkyl, aryl, or a heteroring, which groups may be substituted or unsubitutued; or -(CH2)n-O-?-R1; R5 is lower alkyl or lower alkenyl; Y is hydrogen, lower alkyl wherein a carbon atom within the chain may be replaced by a heteroatom, lower alkoxy, aryl, aryloxy, lower cycloalkyl, lower cycloalkyl lower alkyl, a 4- to 6-member heteroring or -NR2R3; X? is a pharmaceutically acceptable anion, and optically active forms thereof, meso forms thereof, cis-trans isomeric forms thereof and racemates thereof.

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