Nitrogen-containing fused heterocyclic compounds and their...

Details Nitrogen-containing fused heterocyclic compounds and their... Nitrogen-containing fused heterocyclic compounds and their...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4439 (2006.01) C07D 417/14 (2006.01) C07D 471/18 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2753696

A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substi-tuted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by A.beta..

L'invention concerne un composé de formule (I) ou un sel ou ester pharmacologiquement acceptable de celui-ci, et son utilisation en tant qu'agent thérapeutique dirigé contre une maladie provoquée par la bêta-amyloïde (Aß). Dans la formule (I), le cycle A désigne un groupe hétérocyclique aromatique pentagonal ou analogue condensé avec un groupe cyclique non aromatique pouvant être substitué, le cycle B désigne un groupe phényle ou analogue pouvant être substitué, X1 désigne une liaison simple ou analogue, R1 et R2 désignent chacun un groupe alkyle C1-6 ou analogue, m désigne un nombre entier compris entre 0 et 3, et n désigne un nombre entier compris entre 0 et 2.

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