Nitrogen containing heteroaromatics with ortho-substituted...

Details Nitrogen containing heteroaromatics with ortho-substituted... Nitrogen containing heteroaromatics with ortho-substituted...

C - Chemistry, Metallurgy

07

D

C07D 231/14 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) C07D 231/22 (2006.01) C07D 231/24 (2006.01) C07D 249/04 (2006.01) C07D 257/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2314401

The present application describes nitrogen containing heteroaromatics with ortho-substituted P1's and derivatives thereof of Formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D is substituted ortho to G on E and may be CH2NH2, which are useful as inhibitors of factor Xa.

L'invention concerne des hétéroaromatiques contenant de l'azote, présentant des groupes P1 à substitution ortho, ainsi que des dérivés de ceux-ci, de formule (I), ou des sels ou des formes promédicamenteuses de ceux-ci. Dans ladite formule, J représente N ou NH, et D est en position ortho substitué par rapport à G sur E et peut représenter CH¿2?NH¿2?. Lesdits composés, dérivés, sels ou formes promédicamenteuses sont utiles en tant qu'inhibiteurs du facteur Xa.

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