Nitrogen-containing heteroaryl compounds having hiv...

Details Nitrogen-containing heteroaryl compounds having hiv... Nitrogen-containing heteroaryl compounds having hiv...

C - Chemistry, Metallurgy

07

D

C07D 215/28 (2006.01) A61K 31/4184 (2006.01) A61K 31/4188 (2006.01) A61K 31/422 (2006.01) A61K 31/424 (2006.01) A61K 31/4245 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/429 (2006.01) A61K 31/433 (2006.01) A61K 31/4353 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/498 (2006.01) A61K 31/5025 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/5383 (2006.01) A61K 31/542 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A

Patent

CA 2439666

It is found out that compounds represented by the following general formula (I): (I) wherein Z4, Z5 and Z9 independently represent each carbon or nitrogen; Y represents hydroxy, mercapto or amino; and RA represents the group of the following general formula: (wherein the ring C is a nitrogen-containing heteroaryl), etc.; have an integrase inhibitory activity.

On a constaté que les composés représentés par la formule générale (I) dans laquelle Z?4¿, Z?5¿ et Z?9¿ représentent individuellement carbone ou azote ; Y représente hydroxy, mercapto ou amino ; et R?A¿ représente le groupe de formule générale (II) dans laquelle le noyau C est un hétéroaryle azoté , etc. ; exercent un effet inhibiteur sur l'intégrase.

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