Nitrogen containing heterobicycles as factor xa inhibitors

Details Nitrogen containing heterobicycles as factor xa inhibitors Nitrogen containing heterobicycles as factor xa inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/33 (2006.01) A61P 7/02 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2380727

This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.

L'invention se rapporte à des composés hétérobicycliques contenant de l'azote, qui sont représentés par les formules A et B et qui sont des inhibiteurs des sérine-protéases de type trypsine, et notamment du facteur Xa. Elle se rapporte également à des compositions pharmaceutiques contenant ces composés hétérobicycliques et à des méthodes d'utilisation de ces compositions en tant qu'agents anticoagulants pour le traitement et la prévention des troubles thromboemboliques.

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