C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2623813
It is intended to provide a compound represented by the general formula (I): (I) (wherein all the symbols are as defined in the description) which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.
L~invention concerne un composé représenté par la formule générale (I) : (I) (selon laquelle tous les symboles sont définis tels que dans la description) qui a une activité inhibitrice de p38 MAP kinase, un sel, un N-oxyde, un solvate ou un promédicament de ce composé. Le composé de l~invention est utilisé pour prévenir ou traiter une maladie dans laquelle la production anormale d~une cytokine telle qu~une cytokine inflammatoire ou une chimiokine ou une réaction excessive à celles-ci tend à être impliquée dans la cause et l~aggravation d~états pathologiques, en d~autres termes, une maladie inflammatoire, une maladie respiratoire, une maladie cardiovasculaire, une maladie du système nerveux central ou analogues, qui est une maladie transmise par la cytokine.
Hirosaki Tomomi
Nakai Hisao
Nakatani Shingo
Yamamoto Shingo
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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