C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/46 (2006.01) A61K 31/403 (2006.01) A61K 31/445 (2006.01) A61K 31/4468 (2006.01) A61K 31/45 (2006.01) A61K 31/453 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) A61P 43/0
Patent
CA 2517888
A compound represented by the following general formula (I), its salt, solvates thereof or prodrugs thereof: (I) (wherein each symbol is as defined in the description.) The compounds represented by the general formula (I) are useful in preventing and/or treating various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infection with human immunodeficiency virus (acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchoplumonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection, diabetes, cancer metastasis and so on.
L'invention concerne un composé de formule générale (I), y compris sel, solvate ou promédicament correspondant, chaque symbole étant tel que défini dans la description. Les composés en question sont utiles pour la prévention et/ou le traitement de diverses maladies inflammatoires (asthme, néphrite, névropathie, hépatite, arthrite, polyarthrite rhumatoïde, rhinite, conjonctivite, colite ulcéreuse, etc.), de maladies immunologiques (maladies autoimmunes, rejet d'organe transplanté, immunosuppression, psoriasis, sclérose en plaques, etc.), de maladies allergiques (dermatite atopique, urticaire, aspergillose bronchopulmonaire allergique, gastroentérite eosinophilique allergique, etc.), de lésion de reperfusion ischémique, de syndrome de détresse respiratoire aigüe, d'infection bactérienne s'accompagnant d'un choc, de diabète, de métastase cancéreuse, etc.
Nishizawa Rena
Shibayama Shiro
Takaoka Yoshikazu
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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