Nitrogen-containing heterocyclic derivatives, medicinal...

Details Nitrogen-containing heterocyclic derivatives, medicinal... Nitrogen-containing heterocyclic derivatives, medicinal...

C - Chemistry, Metallurgy

07

H

C07H 17/02 (2006.01) A61K 31/706 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/10 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 19/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2509835

It is intended to provide a nitrogen-containing heterocyclic derivative which has an excellent effect of inhibiting human SGLT2 activity and is useful as a preventive or a remedy for diseases caused by hyperglycemia such as diabetes, diabetic complications and obesity, its pharmaceutically acceptable salt, prodrugs thereof, medicinal compositions containing the same and medicinal use thereof: (I) wherein X1 represents N or CR1; X2 represents N or CR2; X3 represents N or CR3; X4 represents N or CR4, provided that 1 or 2 of X1 to X4 are N; R represents optionally substituted C3-8 cycloalkyl, optionally substituted C6-10 aryl, etc.; and R1 to R4 represent each H, a halogen, etc.

L'invention concerne un dérivé hétérocyclique contenant de l'azote avec un excellent effet d'inhibition de l'activité humaine SGLT2, et utilisé dans la prévention ou le traitement des maladies causées par une hyperglycémie, par exemple le diabète, les complications liées au diabète et l'obésité, un sel acceptable d'un point de vue pharmaceutique de celui-ci, des promédicaments de celui-ci, des compositions médicinales contenant celui-ci, et l'utilisation médicale de celui-ci. X?1 ¿représente N ou CR?1¿; X?2¿ représente N ou CR?2¿; X?3¿ représente N ou CR?3¿; X?4¿ représente N ou CR?4¿, à condition que 1 ou 2 de X?1¿ à X?4¿ soit N; R représente un cycloalkyle C¿3-8? éventuellement substitué; un aryle C¿6-10? éventuellement substitué, etc.; et R?1¿ à R?4¿ représentent chacun H, un halogène, etc.

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