Nitrogen-containing macrocyclic conjugates as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 521/00 (2006.01) A61K 31/00 (2006.01) A61K 51/06 (2006.01) A61P 35/00 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2745495

The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.

La présente invention concerne des composés utiles comme ligands de métaux qui peuvent contenir une fraction de reconnaissance moléculaire ou être liés à une telle fraction, et des procédés de fabrication de ces composés. Une fois que les composés contenant une fraction de reconnaissance moléculaire sont coordinés avec un radionucléide métallique approprié, ils deviennent utiles comme produits radiopharmaceutiques dans les domaines de la radiothérapie et de l'imagerie de diagnostic. L'invention concerne également des procédés de diagnostic et de thérapie utilisant les composés radiomarqués ci-décrits.

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