Nitrogen-containing tetracyclic compounds

Details Nitrogen-containing tetracyclic compounds Nitrogen-containing tetracyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) C07D 209/80 (2006.01) C07D 471/04 (2006.01) C07D 491/052 (2006.01)

Patent

CA 2313054

Nitrogen-containing tetracyclic compounds represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein Y1-Y2-Y3 represents N- C=N or C=C-NR3 (wherein R3 represents hydrogen, C1-5 alkyl or nitrogen- containing C2-10 alkyl); Y4 represents S, SO, SO2, CH2 or NR4 (wherein R4 represents C1-5 alkanoyl or C1-5 alkyl); R1 and R2 are the same or different and each represents hydrogen, C1-10 alkyl, C3-15 alkoxyalkyl or C3-15 alkylaminoalkyl, or R1 and R2 form together with the adjacent nitrogen atom cyclic amino; X1 and X2 are the same or different and each represents hydrogen, C1-5 alkyl, C1-5 alkoxy or halogeno; and n is 0, 1 or 2.

L'invention concerne des composés tétracycliques renfermant de l'azote représentés par la formule générale (I) ci-après, ou des sels pharmaceutiquement acceptables de ces composés. Dans ladite formule (I), Y?1¿-Y?2¿-Y?3¿ représente N-C=N ou C=C-NR?3¿ (où R?3¿ représente hydrogène, un C¿1-5? alkyle ou un C¿2-10? alkyle renfermant de l'azote); Y?4¿ représente S, SO, SO¿2?, CH¿2? ou NR?4¿ (où R?4¿ représente un C¿1-5? alkanoyle ou un C¿1-5? alkyle); R?1¿ et R?2¿, qui sont identiques ou différents, représentent chacun hydrogène, un C¿1-10? alkyle, un C¿3-15? alcoxyalkyle ou un C¿3-15? alkylaminoalkyle, ou bien R?1¿ et R?2¿ forment, avec l'atome d'azote adjacent, un groupe amino cyclique; X?1¿ et X?2¿, qui sont identiques ou différents, représentent chacun hydrogène, un C¿1-5? alkyle, un C¿1-5? alcoxy ou un halogéno; et n est égal à 0, 1 ou 2.

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