Nitrogenous heterocyclic compounds, preparation thereof and...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/18 (2006.01) A61K 31/529 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01) C07D 211/56 (2006.01) C07D 241/00 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2683350

The invention relates to nitrogenous heterocyclic compounds, the preparation thereof and the use thereof as antibacterial medicaments, the compounds of general formula (I) in which R1 is a (CH2)n-NH2 or (CH2)n-NHR radical, wherein R is a (C1-C6) alkyl and n is equal to 1 or 2; R2 is a hydrogen atom; R3 and R4 together form a nitrogenous heterocycle of aromatic nature with 5 vertices, containing 1, 2 or 3 nitrogen atoms, optionally substituted with one or more R' groups, wherein R' is selected from the group comprising a hydrogen atom and alkyl radicals containing from 1 to 6 carbon atoms, in free form, in the form of zwitterions, and in the form of salts with pharmaceutically acceptable mineral or organic bases and acids.

L'invention concerne des composés hétérocycliques azotés, leur préparation et leur utilisation comme médicaments antibactériens, les composés de formule générale (I) dans laquelle R1 représente un radical (CH2)n-NH2 ou (CH2) n-NHR, R étant un alkyle (C1-C6) et n étant égal à 1 ou 2; R2 représente un atome d'hydrogène; R3 et R4 forment ensemble un hétérocycle azoté à caractère aromatique à 5 sommets renfermant 1, 2 ou 3 atomes d'azote éventuellement substitué par un ou plusieurs groupements R', R' étant choisi dans le groupe constitué par un atome d'hydrogène et les radicaux alkyle renfermant de 1 à 6 atomes de carbone, sous forme libre, de zwitterions, et sous forme de sels avec les bases et les acides minéraux ou organiques pharmaceutiquement acceptables.

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