Nitrogenous tricyclic compounds and drugs comprising the same

Details Nitrogenous tricyclic compounds and drugs comprising the same Nitrogenous tricyclic compounds and drugs comprising the same

C - Chemistry, Metallurgy

07

D

C07D 279/28 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 219/14 (2006.01) C07D 243/38 (2006.01) C07D 279/22 (2006.01) C07D 279/24 (2006.01) C07D 279/34 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2248820

Novel phenothiazine, acridan, acridone oxime, acridone hydrazone, and dibenzodiazepine derivatives which are effective in the prevention and treatment of diseases in which histamine, leukotriene, etc., participate. Phenothiazine, acridan, acridone oxime, acridone hydrazone, and dibenzodiazepine derivatives represented by general formula (I) (where D represents alkylene, etc.) or pharmacologically acceptable salts thereof are effective in the prevention and treatment of diseases in which chemical transmitters such as histamine and leukotriene participate, for example, asthma, allergic rhinitis, atopic dermatitis, hives, hay fever, gastrointestinal allergy, and dietary allergy, wherein R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and each represents hydrogen, hydroxy, cyano, nitro, optionally substituted carbamoyl, halogeno, lower alkyl optionally substituted by hologeno, etc.; Z represents -S-, -SO-, -SO2-, =NO- substituent, -NC(O)-, or =NN-substituent; and Q represents, for example, - NR20R21 (where R20 and R21 are the same or different and each represents hydrogen, lower alkyl optionally substituted by halogeno, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl, or R20 and R21 may be bonded to each other to thereby form a three- to eight-membered ring in cooperation with the nitrogen atom bonded thereto).

Nouveaux dérivés de phénothiazine, acridan, acridone oxime, acridone hydrazone et dibenzodiazépine efficaces dans la prévention etle traitement de maladies auxquelles participe l'histamine, les leucotriènes, etc. Les dérivés de phénothiazine, acridan, acridone oxime, acridone hydrazone et dibenzodiazépine représentés par la formule générale (I), ou leurs sels pharmacologiquement acceptables, sont efficaces dans la prévention et dans le traitement de maladies auxquelles participent des transmetteurs chimiques tels que l'histamine et les leucotriènes, par exemple l'asthme, les rhinites allergiques, la dermatite atopique, l'urticaire, le rhume des foins, les allergies gastrointestinales et les allergies alimentaires. Dans ladite formule (I), D représente alkylène, etc., R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ sont identiques ou différents et représentent chacun hydrogène, hydroxy, cyano, nitro, carbamoyle facultativement substitué, halogéno, alkyle inférieur facultativement substitué par halogéno, etc.; Z représente -S-, -SO-SO¿2?, un substituant =NO-, -NC(O)-, ou un substituant =NN-;et Q représente, par exemple, -NR?20¿R?21¿ (où R?20¿ et R?21¿ sont identiques ou différents et représentent chacun hydrogène, alkyle inférieur facultativement substitué par halogéno, aryle facultativement substitué, arylalkyle facultativement substitué, hétéroaryle facultativement substitué ou hétéroarylalkyle facultativement substitué, ou R?20¿ et R?21¿ peuvent être liés l'un à l'autre pour former ainsi un cycle de trois à huit éléments en coopération avec l'atome d'azote lié à celui-ci).

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