Nitroimidazole derivatives

Details Nitroimidazole derivatives Nitroimidazole derivatives

C - Chemistry, Metallurgy

07

F

260/305, 260/245

C07F 15/00 (2006.01) C07D 233/91 (2006.01) C07D 233/92 (2006.01)

Patent

CA 1189074

A B S T R A C T Platinum(II)-containing complexes of nitroimidazoles of the formula:- {X]2PtII(z1) 2 I wherein X represents a 2-, 4- or 5-(mono)nitroimidazole molecule which is unsubstituted or carries at least one substituent, and which can coordinate to platinum through the 3-position of the heterocyclic ring, and z1 represents a pharmaceutically-acceptable ligand known not to be capable of coordinating to platinum more strongly than the 3-position nitrogen atom of the imidazole ring of a 2-, 4- or 5-(mono)nitroimidazole molecule represented by the symbol X are of use in the therapy of cancer and in combatting anaerobic bacterial infections.

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