Nitroimidazole radiosensitizers for hypoxic tumor cells and...

Details Nitroimidazole radiosensitizers for hypoxic tumor cells and... Nitroimidazole radiosensitizers for hypoxic tumor cells and...

C - Chemistry, Metallurgy

07

D

260/305, 260/315

C07D 233/91 (2006.01) C07D 235/24 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1197854

ABSTRACT Compounds of the formula: Image (I) wherein W is a cyclic ether containing four or five carbon atoms in the ring or radicals of the formulae: Image ,and R1O-CH2-CH2-O-CH2 in which n is 1 or 2; and R1 is hydrogen or -C(O)-R2 where R2 is lower alkyl, aryl, or arylalkyl; and X and Y when taken separately, are each hydrogen or an electron withdrawing group and, when taken together, form a six membered carbocyclic aromatic ring, and salts of the said compounds with acids. The compounds are useful for radiation therapy of tumor cells.

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