C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/305, 260/315
C07D 233/91 (2006.01) C07D 403/06 (2006.01)
Patent
CA 1104133
ABSTRACT This invention is concerned with novel nitroimidazoles of the general formula Image I , wherein R1 represents a hydrogen atom or a lower alkyl, hydroxy-(lower alkyl), lower cycloalkyl, aryl or lower aralkyl group and R2 represents a lower alkyl, hydroxy-(lower alkyl), lower cyclcalkyl, aryl or lower aralkyl group or a grouping of the formula Image , in which m stands for zero and n stands for 1 or m stands for 1 and n stands for zero and R3 represents a hydrogen atom or the methyl or hydroxy group or a free oxyl radical, or R1 and R2 together with the nitrogen atom to which they are attached represent a pyrrolidino, a piperidino, a morpholino, a piperazino or an azepino group, which pyrrolidino or azepino groups may carry a hydroxy group on a carbon atom other than the carbon atom adjacent to the nitrogen atom and which piperazino group may be substituted by a lower alkyl at nitrogen atom N4, and acid addition salts thereof, useful in sensitising hypoxic cells to the effects of radiation and in combatting protozoal infections, with processes for the manufacture thereof and with pharmaceutical preparations containing same.
309523
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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