Nitromethylthiobenzene derivatives as aldose reductase...

Details Nitromethylthiobenzene derivatives as aldose reductase... Nitromethylthiobenzene derivatives as aldose reductase...

C - Chemistry, Metallurgy

07

C

C07C 317/34 (2006.01) A61K 31/18 (2006.01) C07C 317/40 (2006.01) C07C 317/42 (2006.01) C07C 323/49 (2006.01) C07D 213/71 (2006.01) C07D 307/91 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2275665

The invention concerns novel compounds of general formula (1) in which: P, T1, T2, X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically acceptable bases. The invention also concerns methods for preparing these compounds and their applications as medicines. These compounds inhibit the aldose reductase enzyme and can be used in the treatment or prevention of peripheral and autonomous neurological diabetic complications, renal and ocular disorders such as cataract and retinopathy.

La présente invention concerne de nouveaux composés répondant à la formule générale (1) dans laquelle: P, T1, T2, X et n sont tels que définis à la revendication 1, leurs formes tautomères, et leurs sels d'addition avec des bases pharmaceutiquement acceptables. L'invention concerne aussi des procédés de préparation de ces composés ainsi que les applications de ces composés comme médicaments. Ces composés inhibent l'enzyme aldose réductase et peuvent être utilisés dans le traitement ou la prévention des complications diabétiques neurologiques périphériques et autonomes, rénales et oculaires telles que la cataracte et la rétinopathie.

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