C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 207/00 (2006.01) A61K 31/04 (2006.01) A61K 31/13 (2006.01) A61K 31/277 (2006.01) A61K 31/44 (2006.01) C07D 213/24 (2006.01)
Patent
CA 2502227
Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therapeutics for inflammation-related conditions and analgesia in mammals, such as arthritis, and for neuropathic pain and traumatic injuries such as traumatic brain injury and acute spinal cord injury. The invention accordingly extends to the use of the compounds and compositions for the stated treatments, and as appropriate, to the use of the compounds for the preparation of pharmaceutical compositions for such treatments.
L'invention concerne des composés nitrones et des compositions pharmaceutiques les contenant. Lesdits composés nitrones possèdent un à six atomes de carbone supplémentaires assurant le pontage entre la fonctionnalité nitrone et le cycle nitrone aryle. Les compositions de l'invention sont utiles en tant que produits thérapeutiques pour les états liés à l'inflammation, tels que l'arthrite, pour l'analgésie chez des mammifères et pour la douleur neuropathique, les lésions traumatiques et les lésions aiguës de la moelle épinière. L'invention porte également sur l'utilisation des composés et des compositions pour les traitements mentionnés, et lorsque cela s'avère approprié, sur l'utilisation des composés pour la préparation de compositions pharmaceutiques pour lesdits traitements.
Khan M. Amin
Upasani Ravindra B.
Wood Paul L.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Renovis Inc.
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