Nitrosamine-free 3-isothiazolones and process

Details Nitrosamine-free 3-isothiazolones and process Nitrosamine-free 3-isothiazolones and process

C - Chemistry, Metallurgy

07

D

6/14, 167/9.2, 2

C07D 275/02 (2006.01) A01N 43/80 (2006.01) A61K 31/41 (2006.01) C07D 275/03 (2006.01)

Patent

CA 1189514

ABSTRACT OF THE DISCLOSURE Disclosed herein are biocidal concentrate compositions suitable for applications where substantial human or animal contact is anticipated; and also their method of use and process of preparation. The compositions comprise a stabilized 3-isothiazolone reaction product containing a ring-stabilizing amount of a stabilizing soluble nitrate salt and at least one biologically active 3-isothiazolone of the formula Image wherein R and R' are independently selected from hydrogen, halogen or an alkyl group of 1 to 4 carbon atoms; Y is an alkyl group of 1 to 8 carbon atoms, a cycloalkyl group of 5 or 6 carbon atoms, an aralkyl group of up to 8 carbon atoms, or an aryl or substituted aryl group of 6 carbon atoms, said 3-isothiazolone reaction product containing less than 100 parts of a nitrosamine of the formula Abstract Image and its precursor YNHCH2CH2CONHY, wherein Y is as defined above, for about each 150,000 parts of biologically active 3-isothiazolone.

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