C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/138 (2006.01) A61K 31/165 (2006.01) A61K 31/403 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/5355 (2006.01) C07C 237/40 (2006.01) C07D 209/04 (2006.01)
Patent
CA 2536173
The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at,least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated P-adrenergic antagonists, nitrosated and/or nitrosylated angiotensinconverting enzyme (ACE) inhibitors, nitrosated and/or nitrosylated anti-hyperlipidemic compounds, and nitrosated and/or nitrosylated antithrombotic and vasodilator compounds.
L'invention concerne de nouveaux composés cardiovasculaires nitrosés et/ou nitrosylés ou des sels de ceux-ci pharmaceutiquement acceptables, ainsi que de nouvelles compositions comprenant au moins un composé nitrosé et/ou nitrosylé, et, éventuellement, au moins un donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention concerne également de nouvelles compositions et des trousses comprenant au moins un composé cardiovasculaire selon l'invention, qui est éventuellement nitrosé et/ou nitrosylé, et, éventuellement, au moins un composé de donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention concerne également des procédés permettant de traiter (a) des maladies cardiovasculaires; (b) des maladies réno-vasculaires; (c) des diabètes; (d) des maladies résultant du stress oxydatif; (e) des dysfonctionnements endothéliaux; (f) des maladies provoquées par des dysfonctionnements endothéliaux; (g) la cirrhose; (h) la pré-éclampsie; (j) l'ostéoporose; et (k) la néphropathie. De préférence, les composés cardiovasculaires nitrosés et/ou nitrosylés sont des antagonistes .beta.-adrénergiques nitrosés et/ou nitrosylés, des inhibiteurs de l'enzyme de conversion de l'angiotensine (ACE) nitrosés et/ou nitrosylés, des composés anti-hyperlipidémiques nitrosés et/ou nitrosylés, et des composés vasodilateurs et antithrombotiques nitrosés et/ou nitrosylés.
Garvey David S.
Gaston Ricky D.
Letts L. Gordon
Worcel Manuel
Bennett Jones Llp
Nitromed Inc.
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