C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 1/00 (2006.01) A61K 31/56 (2006.01) A61K 31/58 (2006.01) C07J 17/00 (2006.01) C07J 43/00 (2006.01)
Patent
CA 2518506
The invention describes novel nitrosated and/or nitrosylated compounds of the invention, and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated compound of the invention, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one compound of the invention, that is optionally nitrosated and/or nitrosylated, and at least one nitric oxide donor compound and/or at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for inhibiting platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative or vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering at least one compound of the invention that is optionally nitrosated and/or nitrosylated, in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The compounds of the invention are preferably estradiol compounds, troglitazone compounds, tranilast compounds, retinoic acid compounds, resveratol compounds, myophenolic acid compounds, acid compounds, anthracenone compounds and trapidil compounds.
L'invention concerne de nouveaux composés nitrosés et/ou nitrosylés et des sels de ceux-ci pharmaceutiquement acceptables, de nouvelles compositions comprenant au moins un composé nitrosé et/ou nitrosylé et, éventuellement, au moins un composé donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention concerne également de nouvelles compositions comprenant au moins un composé de l'invention éventuellement nitrosé et/ou nitrosylé, au moins un composé donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. Les composés et les compositions de l'invention peuvent être liés à une matrice. L'invention concerne également des méthodes permettant: de traiter les maladies cardio-vasculaires par inhibition d'agrégations et d'adhérences de plaquettes entraînées par l'exposition du sang à un dispositif médical destiné à traiter des états pathologiques résultant de la prolifération de cellules anormales, les rejets de transplantation, les maladies auto-immunes, inflammatoires, prolifératives, hyperprolifératives ou vasculaires; de réduire un tissu cicatriciel ou d'inhiber une contraction de blessure; et de traiter la resténose de manière prophylactique et/ou thérapeutique par administration d'au moins un composé de l'invention éventuellement nitrosé et/ou nitrosylé en combinaison avec des donneurs d'acide nitrique capables de libérer un oxyde nitrique, et de distribuer ou transférer indirectement un oxyde nitrique vers des sites cibles dans des conditions physiologiques. Les composés de l'invention sont, de préférence, des composés d'estradiol, de troglitazone, de tranilast, d'acide rétinoïde, de resveratol, d'acide myophénolique, d'anthracénone et de trapidil.
Earl Richard A.
Garvey David S.
Gaston Ricky D.
Lin Chia-En
Ranatunge Ramani R.
Bennett Jones Llp
Nicox S.a.
Nitromed Inc.
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