C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/06 (2006.01)
Patent
CA 2539973
The invention describes novel nitrosated glutamic acid compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated glutamic acid compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated glutamic acid compound, and, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating diseases resulting from elevated levels of gamma-glutamyl transpeptidase and (m) the targeted delivery of compounds and nitric oxide to organs, cells or tissues containing the enzyme gamma-glutamyl transpeptidase.
L'invention concerne de nouveaux composés d'acide glutamique nitrosés et leurs sels pharmaceutiquement compatibles, et de nouvelles compositions contenant au moins un composé d'acide glutamique nitrosé, et éventuellement au moins donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention concerne également de nouvelles trousses contenant au moins un composé d'acide glutamique nitrosé et, éventuellement au moins un composé donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention concerne également des procédés permettant de traiter (a) des maladies cardio-vasculaires; (b) des maladies réno-vasculaires; (c) des diabètes; (d) des maladies résultant du stress oxydatif; (e) des dysfonctionnements endothéliaux; (f) des maladies dues aux dysfonctionnements endothéliaux; (g) des cirrhoses; (h) de la pré-éclampsie; (j) de l'ostéoporose; (k) de la néphropathie; (1) de maladies dues à des niveaux élevés de transpeptidase de gamma-glutamyle et de délivrer de manière ciblée (m) ces composés et de l'oxyde nitrique aux organes, cellules ou tissus contenant l'enzyme transpeptidase de gamma-glutamyle.
Earl Richard A.
Ezawa Maiko
Fang Xinqin
Garvey David S.
Gaston Ricky D.
Bennett Jones Llp
Nicox S.a.
Nitromed Inc.
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