C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/22 (2006.01) A61K 31/13 (2006.01) A61K 31/38 (2006.01) C07C 203/00 (2006.01) C07C 291/02 (2006.01) C07C 311/17 (2006.01) C07C 317/18 (2006.01) C07C 323/12 (2006.01) C07C 327/28 (2006.01) C07D 209/18 (2006.01) C07D 211/22 (2006.01) C07D 211/56 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2491127
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
L'invention porte sur de nouveaux m~dicaments anti-inflammatoires non st~ro~diens (NSAID) nitros~s et leurs sels pharmacocompatibles, et sur de nouvelles compositions comprenant au moins un NSAID nitros~ et facultativement au moins un compos~ qui donne, transfert, ou libre de l'oxyde nitrique, stimule la synthse endogne de l'acide nitrique, ~lve les niveaux endognes du facteur relaxant d~rivant de l'endoth~lium, ou sert de substrat de la synthase de l'oxyde nitrique et/ou au moins d'un agent th~rapeutique. L'invention porte ~galement sur de nouvelles compositions comprenant au moins un NSAID nitros~, et au moins un compos~ qui produit, transfert, ou libre de l'oxyde nitrique, stimule la synthse endogne de l'acide nitrique, ~lve les niveaux endognes du facteur relaxant d~rivant de l'endoth~lium, ou sert de substrat de la synthase de l'oxyde nitrique et/ou au moins d'un agent th~rapeutique. L'invention porte en outre sur de nouvelles trousses comprenant au moins un NSAID nitros~ et facultativement un donneur d'oxyde nitrique et/ou au moins un agent th~rapeutique. L'invention porte de plus sur des proc~d~s traitant les inflammations, la douleur, et la fivre; traitant les troubles gastro-intestinaux; favorisant la cicatrisation, traitant ou pr~venant les intoxications gastro-intestinales, r~nales, et/ou respiratoires cons~cutives ~ l'utilisation de compos~s anti-inflammatoires non st~ro~diens; traitant les maladies et/ou troubles inflammatoires; et traitant ou pr~venant les maladies et/ou troubles ophtalmiques.
Earl Richard A.
Ezawa Maiko
Fang Xinqin
Garvey David S.
Gaston Ricky D.
Bennett Jones Llp
Nicox S.a.
Nitromed Inc.
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