Nitrosothiol derivatives, their production and use

Details Nitrosothiol derivatives, their production and use Nitrosothiol derivatives, their production and use

C - Chemistry, Metallurgy

07

K

530/5.04, 167/10

C07K 5/04 (2006.01) A61K 38/04 (2006.01) C07C 381/00 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/093 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2022685

Abstract of the Disclosure Novel nitrosothiol derivatives of the formula: Image wherein R1 and R2 are independently a hydrogen atom or a hydrocarbon residue which may be substituted; R3 is a hydrogen atom, an acyl group or a hydrocarbon residue which may be substituted; X1 is a hydrogen atom, an acyl group, a lower alkoxy group or a hydrocarbon residue which may be substituted; X2 is an acyl group or a carboxyl group which may be esterified or which may form an amide; with proviso that when X2 is a carboxyl group X1 is not a hydrogen atom or acetyl group and that when both R1 and R2 are hydrogen atoms X is not acetyl group or .gamma.-glutamyl group, and salts thereof, show excellent hypotensive action, anti- arrhythmic action, anti-anginal action, cardiotonic action or coronary vasodilation, thus being useful as therapeutic or prophylactic agents for the cardiovascular diseases such as hypertension and anqina pectoris.

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