Nitrosourea compounds and process for preparing the same

Details Nitrosourea compounds and process for preparing the same Nitrosourea compounds and process for preparing the same

C - Chemistry, Metallurgy

07

H

260/228

C07H 5/04 (2006.01) C07H 13/12 (2006.01) C07H 17/00 (2006.01)

Patent

CA 1115696

ABSTRACT OF THE DISCLOSURE A nitrosourea compound of the formula: Image wherein R1 is alicyclic group having 3 to 6 carbon atoms, phenyl, phenyl substituted with one to substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy and nitro, or a heteromonocyclic group selected from oxiranyl, tetrahydro- furyl, 1,3-dioxolanyl, 1,4-dioxanyl, morpholino, tetrahydro- S,S-dioxo-thienyl, furyl, thienyl and pyridyl; R2 is aldo- pentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl or O-aldo-hexopyranosyl-(1?4)-aldo-hexopyranosyl; and A is single bond or straight or branched alkylene having one to 3 carbon atoms, is prepared by nitrosation of a compound of the formula: Image wherein Rl, R2 and A are the same as above. Said nitroso- urea compound is useful as an anti-tumor or anti-leukemic agent.

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