Nitrosourea compounds and process for preparing the same

Details Nitrosourea compounds and process for preparing the same Nitrosourea compounds and process for preparing the same

C - Chemistry, Metallurgy

07

H

260/228

C07H 5/04 (2006.01) C07H 13/12 (2006.01)

Patent

CA 1121347

NOVEL NITROSOUREA COMPOUNDS AND PROCESS FOR PREPARING THE SAME Abstract of the Disclosure The invention relates to nitrosourea compounds of the formula: Image wherein R1 is lower alkoxy, lower alkoxy-methoxy or 2-hydroxy-ethoxy, R2 is aldo-pentofuranosyl, aldo- pentopyranosyl, aldo-hexopyranosyl or O-aldo-hexopyranosyl- (1?4)-aldo-hexopyranosyl, and A is straight or branched alkylene of one to four carbon atoms (the alkylene being optionally substituted with lower alkoxy). These com- pounds may be prepared by nitrosation of a compound of the formula: Image wherein R1, R2 and A are the same as defined above. The nitrosourea compounds are useful as anti-tumor or anti-leukemic agents.

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