Nitrosourea compounds, method for preparing same, and...

C - Chemistry – Metallurgy – 07 – H

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260/230.58

C07H 5/04 (2006.01) C07H 13/12 (2006.01)

Patent

CA 1205073

ABSTRACT OF THE DISCLOSURE The invention provides pharmaceutically active agents of the structural formula Image (I) wherein n is 1 or 2; X is CH2Y where n is 1 and X is CH2Y, or H where n is 2; one of the radicals Y is Z and all other radicals Y are OH; Z is -NR12-CON-CH2-CH2C1; NO R11 is a C3-C10 linear or branched alkyl; a C3-C5 linear or branched alkenyl or alkynyl; a C2-C4 linear or C3-C4 branched alkyl substituted by C1-C4 alkoxy, methoxymethoxy, methoxyethoxy, or hydroxy- ethoxy radicals; C3-8 cycloalkyl; C1-3 alkyl substituted with C3-8 cycloalkyl groups; benzyl; benzyl having 1 to 3 substituents selected from the group consisting of C1-4 alkyl, C1-4 alkoxy and cyclopropyl; phenethyl; tetrahydrofurfuryl, furfuryl; morpholinoethyl, morpholinopropyl; piperidinoethyl; and R12 is a C1-C10 linear or branched alkyl; C3-C5 linear or branched alkenyl or alkynyl; C1-6 hydroxyalkyl; C2-4 linear or C3-C4 branched alkyl substituted by C1-4 alkoxy or C1-4 hydroxyalkoxy; C3-8 cycloalkyl; C1-3 alkyl substituted by a C3-8 cycloalkyl radical; benzyl, chlorobenzyl; benzyl having 1 to 3 substituents selected from the group consisting of C1-4 alkyl and C1-4 alkoxy; tetrahydrofurfuryl; furfuryl; morpholino; morpholinoethyl; morpholinopropyl; thiophen-2-yl methyl; pyridylethyl; and piperidinoethyl.

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