Nitrosylated neuropeptides

Details Nitrosylated neuropeptides Nitrosylated neuropeptides

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/22 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218616

Neuropeptides, particularly vasoactive intestinal peptide (VIP) and fragments, mutations and derivatives thereof that have corresponding activities to which have been directly or indirectly linked at least one NO or NO2 group, and their uses, including the relaxation of smooth muscle in several tissues, including vascular smooth muscle (e.g., aorta) and nonvascular smooth muscle (e.g. trachea, sphincter of Oddi, gastrointestinal smooth muscle and corpus cavernosum smooth muscle), and particularly also for the diagnosis and treatment of human male impotence.

Cette invention concerne des neuropeptides, et particulièrement le peptide intestinal vasoactif (VIP), ainsi que des fragments, des mutations et des dérivés de ces neuropeptides qui ont des activités correspondantes auxquelles a été lié directement ou indirectement au moins un groupe NO ou NO¿2?. L'invention concerne les utilisations de ces neuropeptides, et entre autres, la relaxation de muscle lisse dans différents tissus au nombre desquels on compte des muscles lisses vasculaires (par exemple, l'aorte) et des muscles lisses non vasculaires (par exemple, la trachée, le sphincter d'Oddi, le muscle lisse gastro-intestinal et le muscle lisse de corps caverneux), et elle concerne également une utilisation particulière relative au diagnostic et au traitement de l'impuissance masculine.

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