Nitroxy derivatives of (r) and (s)-carnitine

Details Nitroxy derivatives of (r) and (s)-carnitine Nitroxy derivatives of (r) and (s)-carnitine

C - Chemistry, Metallurgy

07

C

C07C 229/22 (2006.01) A61K 31/22 (2006.01) A61P 9/10 (2006.01) C07B 55/00 (2006.01) C07C 227/16 (2006.01) C07C 227/18 (2006.01) C07C 227/32 (2006.01)

Patent

CA 2379047

New carnitine derivatives of general formula (I) are described in racemic and/or optically active form, as well as the process for their preparation and their use as pharmaceutical anti-angina active ingredients for the treatment of ischaemic heart disease. A further subject of the invention described herein is a process for producing the (R)-carnitine enantiomer from (S)- carnitine (or vice versa), through the use of derivatives of general formula (I).

L'invention concerne de nouveaux dérivés de carnitine correspondant à la formule générale (I) qui sont décrits sous forme racémique et/ou optiquement active. L'invention concerne également le procédé de préparation et d'utilisation de ces dérivés comme matière active pharmaceutique anti-angineuse pour le traitement de la cardiopathie ischémique. En outre, l'invention concerne un procédé de production d'enantiomère (R)-carnitine à partir de (S)-carnitine (ou vice-versa), par le biais de dérivés de la formule générale (I).

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