Nk-1 receptor antagonists and 5ht3 receptor antagonists for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/445 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2164689

The present invention relates to a method of treating or preventing emesis in a mammal, including a human, by administering to the mammal a 5HT3 receptor antagonist and an NK-1 receptor antagonist (e.g., a substance P receptor antagonist). It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a 5HT3 receptor antagonist and an NK-1 receptor antagonist.

La présente invention concerne une méthode pour le traitement ou la prévention des vomissements chez un mammifère, y compris l'homme, par administration au mammifère d'un antagoniste des récepteurs 5HT3 et d'un antagoniste des récepteurs NK-1 (p. ex. un antagoniste des récepteurs de substance P). Elle concerne également des compositions pharmaceutiques renfermant un véhicule pharmacocompatible, un antagoniste des récepteurs 5HT3 et un antagoniste des récepteurs NK-1.

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