Nk-b inhibitors for the treatment of muscular dystrophy

Details Nk-b inhibitors for the treatment of muscular dystrophy Nk-b inhibitors for the treatment of muscular dystrophy

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/365 (2006.01) A61K 31/635 (2006.01) A61K 45/00 (2006.01) A61P 21/00 (2006.01)

Patent

CA 2613337

Compositions and methods for treatment of individuals diagnosed with a dystrophin deficiency are disclosed. In particular, inhibitors of NF.kappa.B activation, such as pyrrolidine dithiocarbamate (PDTC), have been shown to prevent and reverse muscle damage in animals lacking dystrophin. Such compositions and methods are useful in the treatment of individuals with muscular dystrophy.

Compositions et procédés pour le traitement de déficience de dystrophine diagnostiquée, et en particulier il apparaît que les inhibiteurs de l'activation NF?B, du type pyrrolidine dithiocarbamate (PDTC), préviennent et inversent les lésions musculaires chez un animal en déficience de dystrophine. Les compositions et les procédés sont utiles pour le traitement de la dystrophie musculaire..

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