C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/52 (2006.01)
Patent
CA 2509400
The present invention relates generally to compositions useful in therapies involving the selective destruction of tumor cells in vivo. In particular, this invention relates to a conjugate which comprises a target recognition segment and an active cytotoxic segment. The target recognition segment comprises a receptor specific to NK cells, wherein the receptor binds to a cellular ligand expressed on the surface of a tumor cell, and the active segment comprises an agent capable of exerting a cytotoxic effect on the tumor cell. The target recognition segment derived form the natural killer receptor NKp30 has been found to be particularly effective in vivo.
La présente invention se rapporte généralement aux compositions utiles dans des thérapies comprenant la destruction sélective de tumeurs in vivo. Cette invention concerne en particulier un conjugué qui comprend un segment de reconnaissance de cibles et un segment cytotoxique actif. Le segment de reconnaissance de cibles comprend un récepteur spécifique aux cellules NK, dans lequel ledit récepteur se lie à un ligand cellulaire exprimé à la surface d'une cellule tumorale, et le segment actif comprend un agent capable d'exercer un effet cytotoxique sur la cellule tumorale. On a découvert que le segment de reconnaissance de cible, dérivé du récepteur des cellules K naturelles NKp30, est particulièrement efficace in vivo.
Mandelboim Ofer
Porgador Angel
Natspears Ltd.
Ridout & Maybee Llp
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