C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/415 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2416733
The invention relates to a targeting complex, capable of targeting an active substance to a target cell, said complex comprising: a target recognition segment comprising one of NKp46, NKp30, NKp44 or a functional fragment thereof; and an active segment comprising an active substance such as cytotoxic moiety; an imaging moiety; or an Ig fragment. The targeting complex of the invention serves as a therapeutic agents for the treatment of pathologies associated with viral infections or cancer and for the imaging and monitoring of cancer.
L'invention porte sur un complexe de ciblage capable de cibler une substance active d'une cellule cible, ledit complexe comprenant: un segment de reconnaissance de cible comprenant l'une des protéines NKp46, NKp30, NKp44 ou l'un de leurs fragments fonctionnels; et un segment actif comprenant une substance active tel qu'un fragment cytotoxique; un fragment imageur; ou un fragment d'Ig. Le complexe de ciblage de l'invention sert d'agent thérapeutique pour le traitement de pathologies associées à des infections virales ou à des cancers, et pour la visualisation et le suivi de cancers.
Mandelboim Ofer
Porgador Angel
Ben-Gurion University Of The Negev Research And Development Auth
Ridout & Maybee Llp
Yissum Research Development Company Of The Hebrew University Of
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