Nmda receptor modulators and uses thereof

Details Nmda receptor modulators and uses thereof Nmda receptor modulators and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/10 (2006.01) A61K 31/407 (2006.01) A61P 25/00 (2006.01) C07D 487/22 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2740628

Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disordersuch as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

L'invention concerne des composés ayant une puissance améliorée dans la modulation de l'activité du récepteur NMDA. De tels composés sont envisagés pour une utilisation dans le traitement de maladies et de troubles tels que ceux de l'apprentissage, des activités cognitives, et l'analgésie, en particulier pour soulager et/ou réduire la douleur neuropathique. L'invention concerne également des formulations disponibles par voie orale et autres formes d'administration pharmaceutiquement acceptables des composés, comprenant des formulations intraveineuses.

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