Nmr apparatus and method for non-invasive in vivo testing of...

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G01R 33/383 (2006.01) G01R 33/3873 (2006.01) G01R 33/46 (2006.01)

Patent

CA 2316365

A magnet assembly (10) for a small scale NMR spectroscopy apparatus suitable for laboratory or home use, comprising two permanent magnets (11) facing one another, a tapered pole cap (12) on each of the two facing surfaces of the permanent magnets, and a plurality of radially polarized annular canceling magnets (18) disposed about the permanent magnets and pole caps. The design and position of the radially polarized canceling magnets reduces leakage of the magnetic field, to maintain the magnetic field strength and homogeneity within the test region, without a disadvantageous increase in the size, weight and cost of the NMR apparatus. Also provided is a method for in vivo measurement of glucose concentration in a patient's body fluid using NMR spectroscopy. The method comprises spectral editing, e.g. double quantum filtering to isolate scalar coupled resonances of glucose.

L'invention concerne un ensemble magnétique (10) destiné à un appareil de spectroscopie RMN faible densité, lequel peut être utilisé en laboratoire ou avoir un usage domestique. Cet ensemble comprend deux aimants permanents (11) qui se font face, un embout polaire effilé (12) sur chacune de ces surfaces opposées, et plusieurs aimants auxiliaires annulaires (18) radialement polarisés, disposés autour desdits aimants permanents et desdits embouts polaires. La conception et la position des aimants auxiliaires radialement polarisés permet de réduire toute fuite de flux magnétique et ainsi d'entretenir l'intensité et l'homogénéité du champ magnétique à l'intérieur de la zone d'essai, tout en conservant un appareil RMN de même taille, poids, et coût. L'invention concerne également un procédé de mesure in vivo de la concentration glucosique dans le fluide corporel d'un patient par spectroscopie RMN. Le procédé de cette invention consiste par ailleurs en une présentation spectrale par exemple un double filtrage quantique permettant d'isoler les résonances glucosiques qui présentent un couplage factoriel.

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