Nmr device for detection of analytes involving magnetic...

G - Physics – 01 – R

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G01R 33/28 (2006.01) G01R 33/34 (2006.01) G01R 33/465 (2006.01)

Patent

CA 2620861

This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.

L'invention concerne, de manière générale, des dispositifs de détection présentant un ou plusieurs petits puits chacuns entourés par, ou à proximité étroite, d'une micro-bobine RMN, chaque puits contenant un éhantillon liquide présentant des nanoparticules magnétiqeus qui s'auto-assemblent ou se dispersent en présence d'un analyte cible, modifiant ainsi les propriétés RMN mesurées de l'échantillon liquide. Le dispositif peut être utilisé, par exemple, comme unité portable pour un diagnostic sur le lieu d'intervention et/ou une utilisation sur le terrain, ou le dispositif peut être implanté pour la surveillance continue ou intermittente d'une ou de plusieurs espèces biologiques à étudier chez un patient.

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