A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/46
A61K 49/00 (2006.01) A61K 49/06 (2006.01) C07D 259/00 (2006.01) C07F 5/00 (2006.01) C07F 9/38 (2006.01) C07F 13/00 (2006.01) G01R 33/28 (2006.01)
Patent
CA 1321346
ABSTRACT In a method of imaging body tissue in a patient, comprising administering to the patient an effective amount of a pharmaceutical agent for affecting the relaxation times of atoms in body tissues undergoing NMR diagnosis, whereby image contrast is enhanced, said agent comprising an amount, effective to affect such relaxation times, of a paramagnetic, physiologically compatible salt of a physiologically compatible chelate complex of an ion of a lanthanide element of atomic numbers 57-70, or of a transition metal of atomic numbers 21-29, 42, or 44; and a pharmaceutically acceptable carrier, and subjecting the patient to NMR tomography, the improvement wherein said salt of said chelate complex is the calcium or magnesium salt. Such salts are new as are some of the complexing chelates.
542735
Kraft Karl F.
Quay Steven C.
Rocklage Scott M.
Worah Dilip
Amersham Health Salutar Inc.
Borden Ladner Gervais Llp
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