Nmr systems for in vivo detection of analytes

Details Nmr systems for in vivo detection of analytes Nmr systems for in vivo detection of analytes

G - Physics

01

R

G01R 33/28 (2006.01) G01R 33/465 (2006.01)

Patent

CA 2669045

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

L'invention concerne en général des systèmes à résonance magnétique nucléaire (RMN) de détection d'analytes in vivo. Dans certains modes de réalisation, l'invention concerne plus particulièrement des systèmes dans lesquels des nanoparticules superparamagnétiques sont exposées à un champ magnétique et à une excitation radiofréquence (RF) à la fréquence de Larmor ou à proximité de celle-ci, de sorte que l'agrégation et/ou la désagrégation des nanoparticules entraînée(s) par la présence et/ou la concentration d'un analyte donné dans un liquide biologique est/sont détectée(s) in vivo à partir d'une réponse en écho RF surveillée.

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